Diphenhydramine vs Chamomile
OTC antihistamine sleep aid versus traditional herbal tea for occasional sleep issues
Brands: Benadryl, Unisom SleepGels
Drug Class
AntihistamineEffectiveness Rating
Safety Rating
Mechanism of Action
Blocks histamine H1 receptors in the brain to cause sedation
Common Uses
- Occasional insomnia
- Allergies
- Motion sickness
Matricaria chamomilla
Research Quality
moderateEffectiveness Rating
Safety Rating
Active Compounds
Modern Uses
- Mild insomnia
- Anxiety
- Digestive issues
Diphenhydramine provides stronger sedation for sleep initiation. Chamomile offers gentle relaxation with modest sleep benefits.
Both generally safe. Diphenhydramine has anticholinergic effects and tolerance issues. Chamomile extremely safe for most people.
Both very affordable. Chamomile slightly cheaper especially as tea. Similar cost effectiveness.
Diphenhydramine convenient as pill, works in 30 min but causes morning grogginess. Chamomile requires preparation as tea but no hangover.
Diphenhydramine studied as sleep aid. Chamomile has moderate evidence for mild sleep and anxiety benefits.
Related Comparisons
Use diphenhydramine for occasional moderate insomnia, short-term only. Choose chamomile for mild sleep issues, as bedtime ritual, for children, or long-term use.
⚠️ Medical Disclaimer
This comparison is for informational purposes only. Always consult with a qualified healthcare provider before making decisions about medications or supplements.