Sertraline vs 5-HTP
SSRI medication versus serotonin precursor supplement for mood support
Brands: Zoloft
Drug Class
SSRIEffectiveness Rating
Safety Rating
Mechanism of Action
Inhibits serotonin reuptake to enhance mood regulation
Common Uses
- Depression
- Anxiety disorders
- PTSD
Griffonia simplicifolia extract
Research Quality
moderateEffectiveness Rating
Safety Rating
Active Compounds
Modern Uses
- Depression
- Anxiety
- Sleep disorders
Sertraline more effective and reliable for diagnosed conditions. 5-HTP provides modest mood support with less evidence.
Sertraline well-studied safety profile. 5-HTP less research and cannot combine with antidepressants (serotonin syndrome risk).
5-HTP cheaper upfront but sertraline may be more cost-effective for actual depression treatment.
Sertraline requires prescription and regular monitoring. 5-HTP available OTC but dosing less standardized.
Sertraline extensively studied for multiple conditions. 5-HTP has limited but promising research for mood.
Use sertraline for diagnosed depression, anxiety disorders, or OCD. Consider 5-HTP only for mild mood support when you cannot take SSRIs.
⚠️ Medical Disclaimer
This comparison is for informational purposes only. Always consult with a qualified healthcare provider before making decisions about medications or supplements.