Fluoxetine vs St John's Wort
SSRI antidepressant versus herbal alternative for depression management
Brands: Prozac
Drug Class
SSRIEffectiveness Rating
Safety Rating
Mechanism of Action
Selectively inhibits serotonin reuptake to increase serotonin levels in the brain
Common Uses
- Depression
- OCD
- Panic disorder
Hypericum perforatum
Research Quality
strongEffectiveness Rating
Safety Rating
Active Compounds
Modern Uses
- Depression
- Seasonal affective disorder
- Mood disorders
Fluoxetine more effective for moderate-severe depression. St Johns Wort comparable for mild-moderate depression in studies.
Both generally safe but with different side effect profiles. St Johns Wort has extensive drug interactions. Fluoxetine more predictable.
St Johns Wort much cheaper without prescription costs. Fluoxetine expensive without insurance.
Fluoxetine requires prescription and monitoring. St Johns Wort available OTC. Both take 4-6 weeks for full effects.
Both have strong evidence. Fluoxetine extensively studied for depression. St Johns Wort proven for mild-moderate depression.
Use fluoxetine for moderate to severe depression or when natural options are ineffective. Choose St Johns Wort only for mild-moderate depression with no drug interactions.
⚠️ Medical Disclaimer
This comparison is for informational purposes only. Always consult with a qualified healthcare provider before making decisions about medications or supplements.